Triglycerides

Case Studies

• Case Studies

  Quiz of the month – August 2023

  Take this short quiz to test your knowledge on the recently published debate on dyslipidemias titled “Great debate: lipid-lowering therapies should be guided by vascular imaging rather than by circulating biomarkers”.

  CLICK HERE TO VIEW THE DEBATE.

  Eur Heart J. 2023 Jul 1;44(25):2292-2304. doi: 10.1093/eurheartj/ehad275

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• Case Studies

  Quiz of the month – April 2023

  Take our patient case study quiz specially curated for you by our Faculty Member, Prof. Samer Ellahham.

  Case Study: A 65-year-old man with a history of dyslipidemia, type 2 diabetes mellitus and systemic hypertension.

   

  Presentation:	New onset crescendo angina x 5 days culminating Rest pain for the past 2h No history of other vascular events or heart attack, no TIA or stroke Weight: 90 kg Exam: BP 150/85 (slightly elevated), Heart Rate 80 No murmur detected
  Medication:	Valsartan 160 mg daily, Aspirin 81 mg daily, Rosuvastatin 10 mg daily, Metformin 500 mg twice daily
  Labs:	BMI 31kg/m2, waist circumference 101.6 cm (40 inches), (-) tobacco (quit last year – 60-pack-year history) Normal CBC, electrolytes Troponin: Elevated Electrocardiogram:1-2 mm horizontal ST depression infero-lateral leads Chest X-ray: Normal
  Lipid panel:	Total cholesterol (TC) 192 mg/dL HDL-C 46 mg/dL Triglycerides 180 mg/dL (non-fasting) LDL-C 110 mg/dL Non-HDL-C 146 mg/ dL

  What are the first impressions about this patient?

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• Case Studies

  Quiz of the month – February 2023

  Take our patient case study quiz specially curated for you by our Faculty Member, Prof. Stephen Nicholls.

  Case Study: A 58-year-old overweight man with a 10-year history of primary hypercholesterolemia presents for a checkup. At diagnosis of hypercholesterolemia, his LDL-C was 198 mg/dL; his clinician recommended diet and exercise interventions and started atorvastatin 10 mg qd. The patient follows a low saturated-fat diet and exercises daily. However, he could not tolerate higher doses of atorvastatin or rosuvastatin 5 mg or pravastatin 20 mg. Today, his LDL-C is 138 mg/dL, HDL-C 52 mg/dL, and triglycerides 78 mg/dL. He continues to take atorvastatin 10 mg qd.

  You add ezetimibe, and follow-up bloods a month later show an LDL-C of 108 mg/dl. You are not sure if he has ASCVD, so review of prior imaging shows he had a CT scan a year ago to evaluate shortness of breath, and the report comments that he has “moderate coronary artery calcification”. You check and Lp(a) and it is elevated at 200 nmol/L (upper limit of normal is 75 nmol/L).

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• Which of the following might be appropriate at this time?

  a) Change statin to pitavastatin

  b) Add PCSK9 inhibitor (either mAb or inclisiran)

  c) Add bile acid sequestrant

  d) Add icosapent ethyl
  

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